1-(N-Boc-氨乙基)哌嗪合成路线 （共 6 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol 2 h;
参考文献
Ferring B.V.
Patent: EP1449844 A1, 2004 ;
Location in patent: Page 34 ;
EP 1449844 A1
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; 15 h; Autoclave;
参考文献
US2011/294775 A1, ;
Page/Page column 168 ;
反应条件
sodium hydroxide; benzaldehyde in dichloromethane
参考文献
US6518286 B1, ;
US 6518286 B1
反应条件
1: dichloromethane / 1 h / 20 °C 2: hydrogen / palladium 10 on activated carbon / methanol / 15 h / 20 °C / Autoclave View Scheme
反应条件
potassium carbonate; sodium iodide in acetone 18 h; Reflux;
参考文献
Sarkis, Manal; Tran, Diem Ngan; Kolb, Stephanie; Miteva, Maria A.; Villoutreix, Bruno O.; Garbay, Christiane; Braud, Emmanuelle
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7345 - 7350
反应条件
1: dichloromethane / 1 h / 20 °C 2: hydrogen / palladium 10 on activated carbon / methanol / 15 h / 20 °C / Autoclave View Scheme
