3',4'-二甲氧基异苯丁酮合成路线 （共 12 条）
反应条件
(i) NaNH2, toluene, (ii) /BRN= 969135/; Multistep reaction;
参考文献
Moffett,R.B. et al.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 178 - 186
反应条件
potassium hydroxide; sodium hydroxide; hydroxylamine hydrochloride; potassium tert-butylate; sodium acetate; acetic anhydride in methanol; water; acetic acid; toluene
参考文献
Alfa Chemicals Italiana S.r.l.
Patent: EP285890 A2, 1988 ;
反应条件
chromium(VI) oxide; sulfuric acid in acetone
Jones's reaction;
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
aluminium trichloride in 1,2-dichloro-ethane
T=35°C; 1 h;
参考文献
Schneider; Ball
Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 75 - 79
反应条件
1: in tetrahydrofuran
T=0°C; Green chemistry;
2: With [bis(acetoxy)iodo]benzene
T=0 - 20°C; Green chemistry;
参考文献
Sagara, Prateep Singh; Chebolu, Rajesh; Bahuguna, Ashish; Ravikumar
RSC Advances, 2014 , vol. 4, # 29 p. 15011 - 15013
参考文献
Mitsui Toatsu Chemicals, Incorporated
Patent: US4985458 A1, 1991 ;
反应条件
PPA
T=60°C; Friedel-Crafts acylation; 15 h;
参考文献
Kraft, Philip; Eichenberger, Walter
European Journal of Organic Chemistry, 2003 , # 19 p. 3735 - 3743
反应条件
trifluorormethanesulfonic acid; titanium(IV) chloride tris(trifluoromethanesulfonate) in acetonitrile
12 h; Ambient temperature;
参考文献
Izumi, Jun; Mukaiyama, Teruaki
Chemistry Letters, 1996 , # 9 p. 739 - 740
反应条件
1: methanesulfonic acid / CH2Cl2 / 4 h / -20 - 0 °C
2: 1.92 g / CH2Cl2 / 18.5 h / -20 - 18 °C
View Scheme
参考文献
Mattson, Matthew N.; Rapoport, Henry
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 6071 - 6074
反应条件
1: 74 percent / magnesium / tetrahydrofuran / 2 h / 20 °C
2: 82 percent / CrO3; aq. H2SO4 / acetone
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
