potassium hydroxide in water

potassium hydroxide in butan-1-ol 2 h; Heating;

1: Na2CO3 / 1,2-dichloro-ethane / 1) 0 deg C, 2) reflux 2: 1) CH3OH, 2) NaOH / 1) r.t., 15 min, 50 deg C, 15 min, 2) water View Scheme

1: 83 percent / HOAc, conc. HCl / 2 h / 120 °C 2: Na2CO3 / 1,2-dichloro-ethane / 1) 0 deg C, 2) reflux 3: 1) CH3OH, 2) NaOH / 1) r.t., 15 min, 50 deg C, 15 min, 2) water View Scheme

1: 76 percent / tetrahydrofuran / 70 °C 2: 83 percent / HOAc, conc. HCl / 2 h / 120 °C 3: Na2CO3 / 1,2-dichloro-ethane / 1) 0 deg C, 2) reflux 4: 1) CH3OH, 2) NaOH / 1) r.t., 15 min, 50 deg C, 15 min, 2) water View Scheme

1: 76 percent / tetrahydrofuran / 70 °C 2: 83 percent / HOAc, conc. HCl / 2 h / 120 °C 3: Na2CO3 / 1,2-dichloro-ethane / 1) 0 deg C, 2) reflux 4: 1) CH3OH, 2) NaOH / 1) r.t., 15 min, 50 deg C, 15 min, 2) water View Scheme