4,6-二氯-5-(2,2-二乙氧基乙基)嘧啶合成路线

参考文献

MILLENNIUM PHARMACEUTICALS, INC.; AMIDON, Benjamin, S.; CARDIN, David, P.; GOULD, Alexandra, E.; GREENSPAN, Paul, D.; HARRISON, Sean, J.
Patent: WO2014/22744 A1, 2014 ;
Location in patent: Paragraph 0110 ;

16019-33-34,6-二氯嘧啶-5-乙醛

14052-82-54,6-二氯-5-(2,2-二乙氧基乙基)嘧啶

参考文献

PFIZER LIMITED; ANDREWS, Mark, David; BAGAL, Sharanjeet, Kaur; BROWN, David, Graham; GIBSON, Karl, Richard; OMOTO, Kiyoyuki; RYCKMANS, Thomas; SABNIS, Yogesh; SKERRATT, Sarah, Elizabeth; STUPPLE, Paul, Anthony
Patent: WO2014/53967 A1, 2014 ;
Location in patent: Page/Page column 164; 165 ;

16019-31-15-烯丙基-4,6-二氯嘧啶

14052-82-54,6-二氯-5-(2,2-二乙氧基乙基)嘧啶

参考文献

SCHERING CORPORATION; NEELAMKAVIL, Santhosh, Francis; BISWAS, Dipshikha; CHACKALAMANNIL, Samuel; NEUSTADT, Bernard, R.; STAMFORD, Andrew; LIU, Hong
Patent: WO2011/62885 A1, 2011 ;

16019-30-05-烯丙基-4,6-二羟基嘧啶

14052-82-54,6-二氯-5-(2,2-二乙氧基乙基)嘧啶

参考文献

BRISTOL-MYERS SQUIBB COMPANY; WANG, Tao; KADOW, John, F.; MEANWELL, Nicholas, A.; HAMANN, Lawrence, G.
Patent: WO2013/138436 A1, 2013 ;

2049-80-1烯丙基丙二酸二乙酯

14052-82-54,6-二氯-5-(2,2-二乙氧基乙基)嘧啶

参考文献

BRISTOL-MYERS SQUIBB COMPANY; WANG, Tao; KADOW, John, F.; MEANWELL, Nicholas, A.; HAMANN, Lawrence, G.
Patent: WO2013/138436 A1, 2013 ;