3-甲基-1H-吲哚-7-甲醛合成路线 （共 4 条）
反应条件
1: 1-(2,2-diethylbutanoyl)-3-methylindole With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether; hexane; cyclohexane T=-78°C; Metallation; 1 h; 2: N,N-dimethyl-formamide T=-78°C; Formylation; 1 h;
参考文献
Fukuda, Tsutomu; Maeda, Ryoichi; Iwao, Masatomo
Tetrahedron, 1999 , vol. 55, # 30 p. 9151 - 9162
反应条件
1.1: NaH / tetrahydrofuran / 1 h / 0 °C 1.2: 96 percent / tetrahydrofuran / 1 h / 20 °C 2.1: sec-BuLi; TMEDA / diethyl ether; hexane; cyclohexane / 1 h / -78 °C 2.2: 14 percent / 1 h / -78 °C View Scheme
参考文献
Fukuda, Tsutomu; Maeda, Ryoichi; Iwao, Masatomo
Tetrahedron, 1999 , vol. 55, # 30 p. 9151 - 9162
反应条件
1: toluene-4-sulfonic acid / toluene / Reflux 2: tetrahydrofuran / -40 - 20 °C View Scheme
参考文献
Lo, Ho Yin; Nemoto, Peter A.; Kim, Jin Mi; Hao, Ming-Hong; Qian, Kevin C.; Farrow, Neil A.; Albaugh, Daniel R.; Fowler, Danielle M.; Schneiderman, Richard D.; Michael August; Martin, Leslie; Hill-Drzewi, Melissa; Pullen, Steven S.; Takahashi, Hidenori; De Lombaert, Stephane
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4533 - 4539
反应条件
in tetrahydrofuran T=-40 - 20°C;
参考文献
Lo, Ho Yin; Nemoto, Peter A.; Kim, Jin Mi; Hao, Ming-Hong; Qian, Kevin C.; Farrow, Neil A.; Albaugh, Daniel R.; Fowler, Danielle M.; Schneiderman, Richard D.; Michael August; Martin, Leslie; Hill-Drzewi, Melissa; Pullen, Steven S.; Takahashi, Hidenori; De Lombaert, Stephane
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4533 - 4539
