2-甲基-2-丙基(3S)-3-(叠氮基甲基)-1-哌啶羧酸酯合成路线 （共 4 条）
反应条件
sodium azide in N,N-dimethyl-formamide T=50°C; 24 h;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 23 p. 3889 - 3901
反应条件
1: NEt3 / CH2Cl2 / 1.5 h / 0 °C 2: sodium azide / dimethylformamide / 24 h / 50 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 23 p. 3889 - 3901
反应条件
hydrogen; palladium on activated charcoal in ethanol P=7500.6 Torr; 1.5 h; Ambient temperature;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1213281 A1, 2002 ;
反应条件
1: H2 / Pd/C / ethanol / 1.5 h / 7500.6 Torr / Ambient temperature
2: tetrabutylammonium hydrogen sulfate, aq. 1 N NaOH / hexane / 3 h / Ambient temperature
View Scheme
参考文献
Hilpert; Ackermann; Banner; Gast; Gubernator; Hadvary; Labler; Muller; Schmid; Tschopp; Van de Waterbeemd
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3889 - 3901
