(S)-1-Boc-3-氨甲基哌啶合成路线 （共 8 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Sagara, Yufu; Mitsuya, Morihiro; Uchiyama, Minaho; Ogino, Yoshio; Kjmura, Toshifumi; Ohtake, Norikazu; Mase, Toshiaki
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 4 p. 437 - 440
反应条件
1: Et3N / ethyl acetate 2: NaN3 / dimethylformamide 3: 100 percent / H2 / Pd/C / methanol View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 53, # 4 p. 437 - 440
反应条件
1: NaN3 / dimethylformamide 2: 100 percent / H2 / Pd/C / methanol View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 53, # 4 p. 437 - 440
反应条件
1: LAH / tetrahydrofuran 2: tetrahydrofuran 3: Et3N / ethyl acetate 4: NaN3 / dimethylformamide 5: 100 percent / H2 / Pd/C / methanol View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 53, # 4 p. 437 - 440
反应条件
1: tetrahydrofuran 2: Et3N / ethyl acetate 3: NaN3 / dimethylformamide 4: 100 percent / H2 / Pd/C / methanol View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 53, # 4 p. 437 - 440
反应条件
sodium tris(acetoxy)borohydride in dichloromethane; water 4 h;
参考文献
Helicon Therapeutics, Inc.
Patent: US2009/62252 A1, 2009 ;
Location in patent: Page/Page column 42 ;
US 20090062252 A1
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in hexane 3 h; Ambient temperature;
参考文献
Hilpert; Ackermann; Banner; Gast; Gubernator; Hadvary; Labler; Muller; Schmid; Tschopp; Van de Waterbeemd
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3889 - 3901
反应条件
triethylamine in dichloromethane T=0°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/71936 A1, 2007 ;
Location in patent: Page/Page column 85-86 ;
