2-甲基-2-丙基(3S)-3-({[(苄氧基)羰基]氨基}甲基)-1-哌啶羧酸酯合成路线 （共 5 条）
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in hexane 3 h; Ambient temperature;
参考文献
Hilpert; Ackermann; Banner; Gast; Gubernator; Hadvary; Labler; Muller; Schmid; Tschopp; Van de Waterbeemd
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3889 - 3901
反应条件
triethylamine in dichloromethane T=0°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/71936 A1, 2007 ;
Location in patent: Page/Page column 85-86 ;
反应条件
1: 98 percent / NEt3 / CH2Cl2 / 1.5 h / 0 °C 2: 98 percent / sodium azide / dimethylformamide / 24 h / 50 °C 3: 98 percent / H2 / Pd/C / ethanol / 1.5 h / 7500.6 Torr / Ambient temperature 4: 100 percent / tetrabutylammonium hydrogen sulfate, aq. 1 N NaOH / hexane / 3 h / Ambient temperature View Scheme
参考文献
Hilpert; Ackermann; Banner; Gast; Gubernator; Hadvary; Labler; Muller; Schmid; Tschopp; Van de Waterbeemd
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3889 - 3901
反应条件
1: 98 percent / H2 / Pd/C / ethanol / 1.5 h / 7500.6 Torr / Ambient temperature 2: 100 percent / tetrabutylammonium hydrogen sulfate, aq. 1 N NaOH / hexane / 3 h / Ambient temperature View Scheme
参考文献
Hilpert; Ackermann; Banner; Gast; Gubernator; Hadvary; Labler; Muller; Schmid; Tschopp; Van de Waterbeemd
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3889 - 3901
反应条件
1: 98 percent / sodium azide / dimethylformamide / 24 h / 50 °C 2: 98 percent / H2 / Pd/C / ethanol / 1.5 h / 7500.6 Torr / Ambient temperature 3: 100 percent / tetrabutylammonium hydrogen sulfate, aq. 1 N NaOH / hexane / 3 h / Ambient temperature View Scheme
参考文献
Hilpert; Ackermann; Banner; Gast; Gubernator; Hadvary; Labler; Muller; Schmid; Tschopp; Van de Waterbeemd
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3889 - 3901
