噻吩并[2,3-d]嘧啶-4(3H)-酮合成路线 （共 26 条）
反应条件
in dichloromethane; N,N-dimethyl-formamide 3 h; Reflux;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN RandD; De Jonghe, Steven; Gao, Ling-Jie; Herdewijn, Piet; Herman, Jean; Jang, Miyeon; Leyssen, Pieter; Louat, Thierry; Neyts, Johan; Pannecouque, Christophe; Vanderhoydonck, Bart
Patent: US2013/190297 A1, 2013 ;
Location in patent: Paragraph 1213; 1214; 1215 ;
反应条件
1: POCl3, Py 3: NH3 / methanol View Scheme
参考文献
Robba,M. et al.
Bulletin de la Societe Chimique de France, 1975 , p. 592 - 597
反应条件
1: POCl3, Py
View Scheme
参考文献
Robba,M. et al.
Bulletin de la Societe Chimique de France, 1975 , p. 592 - 597
反应条件
1.1: bromine; acetic acid / 4 h / 20 °C
2.1: trichlorophosphate / 6 h / Reflux
3.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
4.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
4.2: 0.33 h
View Scheme
参考文献
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; MARUGAN, Juan, J.; ZHENG, Wei; SOUTHALL, Noel; HUANG, Wenwei; MCCOY, Joshua, G.; TITUS, Steven; PATNAIK, Samarjit
Patent: WO2012/44993 A1, 2012 ;
反应条件
1: 4 h / Heating
2: stannic chloride / 1,2-dichloro-ethane / 18 h / Ambient temperature
3: NH3 / methanol / 24 h / Ambient temperature
View Scheme
参考文献
Patil, Vemanna D.; Wise, Dean S.; Wotring, Linda L.; Bloomer, Linda C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 423 - 427
反应条件
sulfuric acid; nitric acid
参考文献
Robba,M. et al.
Bulletin de la Societe Chimique de France, 1975 , p. 587 - 591
Full Text Show Details
Robba,M. et al.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1968 , vol. 267, p. 697 - 700
