4-氯噻吩[2,3-D]嘧啶合成路线 （共 15 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=0°C; 3 h; Reflux;
参考文献
Katholieke Universiteit Leuven, K.U. Leuven RandD; Herman, Jean; Louat, Thierry
Patent: US2014/88088 A1, 2014 ;
Location in patent: Paragraph 1228-1230 ;
反应条件
in N,N-dimethyl-formamide
参考文献
Warner-Lambert Company
Patent: US5654307 A1, 1997 ;
US 5654307 A
反应条件
in dichloromethane; N,N-dimethyl-formamide 3 h; Reflux;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN RandD; De Jonghe, Steven; Gao, Ling-Jie; Herdewijn, Piet; Herman, Jean; Jang, Miyeon; Leyssen, Pieter; Louat, Thierry; Neyts, Johan; Pannecouque, Christophe; Vanderhoydonck, Bart
Patent: US2013/190297 A1, 2013 ;
Location in patent: Paragraph 1213; 1214; 1215 ;
反应条件
1: 79 percent / H2SO4 / 0.25 h / 90 °C / microwave irradiation 2: 90 percent / POCl3 / 20 h / 95 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 48, # 30 p. 5261 - 5264
反应条件
1: 61 percent / 1.5 h / Heating 2: 90 percent / POCl3 / 20 h / 95 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 48, # 30 p. 5261 - 5264
反应条件
2: NaOH / H2O View Scheme
参考文献
Robba,M. et al.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1968 , vol. 266, p. 128 - 130
反应条件
hydrogen; nickel in methanol
参考文献
Robba,M. et al.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1968 , vol. 266, p. 128 - 130
反应条件
n-butyllithium; carbon tetrabromide in tetrahydrofuran; hexane T=-78°C; 2.41667 h;
参考文献
US2013/190297 A1, ;
Paragraph 1216; 1217; 1218 ;
反应条件
carbon tetrabromide in tetrahydrofuran T=-78 - 20°C;
参考文献
Katholieke Universiteit Leuven, K.U. Leuven RandD; Herman, Jean; Louat, Thierry
Patent: US2014/88088 A1, 2014 ;
Location in patent: Paragraph 1231-1233 ;
参考文献
Robba,M. et al.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1968 , vol. 266, p. 128 - 130
