3-[2-(1,3-二氢-1,3-二氧代-2H-异吲哚-2-基)乙基]-6-氟-1H-吲哚-4-羧酸甲酯合成路线 （共 2 条）
反应条件
methylamine in water T=20°C; 17 h; Large scale;
参考文献
Gillmore, Adam T.; Badland, Matthew; Crook, Clare L.; Castro, Nieves M.; Critcher, Douglas J.; Fussell, Steven J.; Jones, Katherine J.; Jones, Matthew C.; Kougoulos, Eleftherios; Mathew, Jinu S.; McMillan, Lynne; Pearce, John E.; Rawlinson, Fiona L.; Sherlock, Alexandra E.; Walton, Robert
Organic Process Research and Development, 2012 , vol. 16, # 12 p. 1897 - 1904
反应条件
1.1: methylamine / water / 17 h / 20 °C / |Large scale 2.1: pyridinium tribromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / |Large scale 3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / |Large scale 3.2: 9 h / 20 °C / |Large scale 4.1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / |Large scale 5.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 12 p. 1897 - 1904
