5-氧代-2-氮杂双环[2.2.1]庚烷-2-甲酸苄酯合成路线 （共 6 条）
反应条件
jones reagent in acetone 3 h; Ambient temperature;
参考文献
Carroll, F. Ivy; Abraham, Phillip; Chemburkar, Sanjay; He, Xu-Chang; Mascarella, S. Wayne; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2184 - 2191
反应条件
1: Na2CO3 / H2O / 2 h / 0 °C 2: 1.) Hg(OAc)2, 2.) 0.5 M NaBH4 in 3 N NaOH / 1.) H2O, THF, RT, 12 h, 2.) H2O, THF, 0 deg C 3: 62 percent / Jones reagent / acetone / 3 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 12 p. 2184 - 2191
反应条件
1: NH4Cl / H2O / 36 h / Ambient temperature 2: Na2CO3 / H2O / 2 h / 0 °C 3: 1.) Hg(OAc)2, 2.) 0.5 M NaBH4 in 3 N NaOH / 1.) H2O, THF, RT, 12 h, 2.) H2O, THF, 0 deg C 4: 62 percent / Jones reagent / acetone / 3 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 12 p. 2184 - 2191
反应条件
1: Na2CO3 / H2O / 2 h / 0 °C 2: 1.) Hg(OAc)2, 2.) 0.5 M NaBH4 in 3 N NaOH / 1.) H2O, THF, RT, 12 h, 2.) H2O, THF, 0 deg C 3: 62 percent / Jones reagent / acetone / 3 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 12 p. 2184 - 2191
反应条件
1: 1.) Hg(OAc)2, 2.) 0.5 M NaBH4 in 3 N NaOH / 1.) H2O, THF, RT, 12 h, 2.) H2O, THF, 0 deg C 2: 62 percent / Jones reagent / acetone / 3 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 12 p. 2184 - 2191
反应条件
1: sodium acetate; hydroxylamine hydrochloride / aq. ethanol / 0.75 h / 20 °C 2: 1.08 g / trimethylsilylpolyphosphate / CH2Cl2 / 12 h / 20 °C View Scheme
参考文献
Chytil, Milan; Engel, Sharon R.; Fang, Qun Kevin
Patent: US2011/65694 A1, 2011 ;
