1,2,3,4-四氢异喹啉 盐酸盐合成路线 （共 8 条）
反应条件
in toluene 6 h; Reflux;
参考文献
Heteroatom Chemistry, , vol. 23, # 6 p. 560 - 567
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 48, # l p. 1759 - 1764
反应条件
in ethanol; water addn. of aq. HCl to the ethanol soln. (cooling, stirring), stirring for 30min, refluxing for 30min;;
参考文献
Chem. Pharm. Bull. (Tokyo), , vol. 14, p. 1382 - 1388
B: B-Verb.14, 3.14.1, page 144 - 145
反应条件
triethylamine in dichloromethane T=20°C; 17 h;
参考文献
Ludwig, Matthias; Hoesl, Cornelia E.; Hoefner, Georg; Wanner, Klaus T.
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 8 p. 1003 - 1010
参考文献
Burger; Mosettig
Journal of the American Chemical Society, 1936 , vol. 58, p. 1570
反应条件
1: 89 percent / NEt3 / CH2Cl2 / 17 h / 20 °C 2: Ph3C(1+)*BF4(1-) / CH2Cl2 / 16 h / 20 °C 3: 0.928 g / CH2Cl2; tetrahydrofuran / 4 h / cooling 4: 91 percent / hydrogen / Pd/C oxidized form / methanol / 16 h / 20 °C / atmospheric pressure View Scheme
参考文献
Ludwig, Matthias; Hoesl, Cornelia E.; Hoefner, Georg; Wanner, Klaus T.
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 8 p. 1003 - 1010
反应条件
n-butyllithium
1.) THF, hexane, -50 deg C, 0.5 h, 2.) THF, hexane, from -50 deg C to RT, 3 h; Yield given. Multistep reaction;
参考文献
Almena, Juan; Foubelo, Francisco; Yus, Miguel
Tetrahedron, 1996 , vol. 52, # 25 p. 8545 - 8564
反应条件
1: 94 percent / NaNO3 / H2O; acetic acid / 2 h / Ambient temperature
2: 86 percent / TiCl4, Mg / 1,2-dichloro-ethane; diethyl ether / 0.5 h / Ambient temperature
View Scheme
参考文献
Landriani; Barlocco; Pinna; Demontis; Miele; Enrico; Anania
Farmaco, 1989 , vol. 44, # 11 p. 1059 - 1068
