(E)-3,7-二甲基-2,6-辛二烯醛合成路线 （共 128 条）
反应条件
1: 1.) BuLi / 1.) THF, hexane, -60 deg C, 15 min; 2.) THF, hexane, -50 deg C, 1 h
2: 70 percent / diethyl ether / 3 h / 0 °C
3: 85 percent / NaH / tetrahydrofuran / 0 deg C, then Rt 1 h
4: 1.) Dibal; 2.) silica gel / 1.) petroleum ether, hexane, -60 deg C, then 10 deg C over 1.5 h; 2.) petroleum ether, hexane, water, -30 deg C, then 0 deg C, 1 h
View Scheme
参考文献
Gebhard, R.; Courtin, J. M. L.; Shadid, J. B.; Haveren, J. van; Haeringen, C. J. van; Lugtenburg, J.
Recueil des Travaux Chimiques des Pays-Bas, 1989 , vol. 108, # 6 p. 207 - 214
反应条件
acetic anhydride in benzene
1 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Takabe, Kunihiko; Yamada, Takashi; Katagiri, Takao
Synthetic Communications, 1983 , vol. 13, # 4 p. 297 - 302
反应条件
tetrapropylammonium perruthennate; oxygen in isopropyl alcohol
Oxidation; Isomerization; Product distribution; Further Variations:SolventsReagents;
参考文献
Marko, Istvan E.; Gautier, Arnaud; Tsukazaki, Masao; Llobet, Antoni; Plantalech-Mir, Elena; Urch, Christopher J.; Brown, Stephen M.
Angewandte Chemie - International Edition, 1999 , vol. 38, # 13-14 p. 1960 - 1962
反应条件
in ethanol
T=419°C; Supercritical conditions;
参考文献
Anikeev; Ermakova; Chibiryaev; Kozhevnikov
Kinetics and Catalysis, 2010 , vol. 51, # 2 p. 162 - 193
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane; water
3 h; Ambient temperaturecleavage of (p-methoxybenzyloxy)methyl protecting group;
参考文献
Kozikowski, Alan P.; Wu, Jiang-Ping
Tetrahedron Letters, 1987 , vol. 28, # 43 p. 5125 - 5128
反应条件
in ethanol
T=381°C; Supercritical conditions;
参考文献
Anikeev; Ermakova; Chibiryaev; Kozhevnikov
Kinetics and Catalysis, 2010 , vol. 51, # 2 p. 162 - 193
反应条件
potassium hydroxide; 2-Nitropropane; isopropyl alcohol
参考文献
Montavon et al.
Helvetica Chimica Acta, 1957 , vol. 40, p. 1250,1253
Full Text Show Details
Nasarow et al.
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 3965,3966,3967;engl.Ausg.S.3925,3927
反应条件
1: 2.) H2O / 1.) THF, -110 deg C, 5 min and -80 deg C, 15 min 2.) addition of ether, room temperature, 3 h
2: meta-chloroperbenzoic acid
View Scheme
参考文献
Williams, David R.; Nishitani, Kiyoshi
Tetrahedron Letters, 1980 , vol. 21, p. 4417 - 4420
反应条件
3-chloro-benzenecarboperoxoic acid
Yield given. Yields of byproduct given;
参考文献
Williams, David R.; Nishitani, Kiyoshi
Tetrahedron Letters, 1980 , vol. 21, p. 4417 - 4420
反应条件
1: phosphoric acid
2: silver acetate
View Scheme
参考文献
Saucy et al.
Helvetica Chimica Acta, 1959 , vol. 42, p. 1945,1954
