1-[(2R,4S,5S)-5-(羟基甲基)-4-甲基氨基四氢呋喃-2-基]-5-甲基嘧啶-2,4-二酮合成路线 （共 6 条）
反应条件
Dowex 50Wx2 (H+) in methanol; water
参考文献
Celewicz; Urjasz; Golankiewicz
Nucleosides and Nucleotides, 1993 , vol. 12, # 9 p. 951 - 966
反应条件
1: 87 percent / sodium azide / ethane-1,2-diol / 0.75 h / 120 °C 2: 93 percent / sodium borohydride / propan-2-ol / 14 h / 82 °C 3: sodium acetate trihydrate, glacial acetic acid / ethanol; H2O / 0.08 h / 0 - 5 °C 4: sodium borohydride / ethanol; H2O 5: 80 percent / Dowex 50Wx2 (H+) / methanol; H2O View Scheme
参考文献
Celewicz; Urjasz; Golankiewicz
Nucleosides and Nucleotides, 1993 , vol. 12, # 9 p. 951 - 966
反应条件
1: sodium acetate trihydrate, glacial acetic acid / ethanol; H2O / 0.08 h / 0 - 5 °C 2: sodium borohydride / ethanol; H2O 3: 80 percent / Dowex 50Wx2 (H+) / methanol; H2O View Scheme
参考文献
Celewicz; Urjasz; Golankiewicz
Nucleosides and Nucleotides, 1993 , vol. 12, # 9 p. 951 - 966
反应条件
1: 93 percent / sodium borohydride / propan-2-ol / 14 h / 82 °C 2: sodium acetate trihydrate, glacial acetic acid / ethanol; H2O / 0.08 h / 0 - 5 °C 3: sodium borohydride / ethanol; H2O 4: 80 percent / Dowex 50Wx2 (H+) / methanol; H2O View Scheme
参考文献
Celewicz; Urjasz; Golankiewicz
Nucleosides and Nucleotides, 1993 , vol. 12, # 9 p. 951 - 966
反应条件
triphenylphosphine 1.) dioxane, room temperature, 24 h, 2.) reflux, 40 min; Yield given. Multistep reaction;
参考文献
Jasko; Fedorov; Atrazhev; Mozzherin; Novicov; Bochkarev; Gurskaya; Krayevsky
Nucleosides and Nucleotides, 1995 , vol. 14, # 1-2 p. 23 - 37
反应条件
sodium tetrahydroborate 1.) EtOH, room temperature, 48 h, 2.) 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Jasko; Fedorov; Atrazhev; Mozzherin; Novicov; Bochkarev; Gurskaya; Krayevsky
Nucleosides and Nucleotides, 1995 , vol. 14, # 1-2 p. 23 - 37
