1: Indole-3-propionic acid With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: benzyl bromide in N,N-dimethyl-formamide 1 h; Further stages.;

hydrogenchloride in hexane; ethyl acetate; N,N-dimethyl-formamide; mineral oil

暂无反应条件数据

sodium hydroxide in ethanol Heating;

1: 92 percent / aq. HCl / Heating 2: Cs2CO3 / acetonitrile 3: aq. NaOH / ethanol / 2 h / Heating View Scheme

1: Cs2CO3 / acetonitrile 2: aq. NaOH / ethanol / 2 h / Heating View Scheme

water; potassium hydroxide

1.1: sodium hydride / mineral oil; ethylene glycol dimethyl ether / 1 h / 20 °C / |Inert atmosphere 1.2: 2 h / -15 - 20 °C / |Inert atmosphere 2.1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / 6 h / 20 °C 3.1: dichloromethane / 0.25 h / 20 °C 3.2: 20 °C 4.1: 20 palladium(II) hydroxide on carbon; hydrogen / tetrahydrofuran; methanol / 67 h / 20 °C / 3750.38 Torr 5.1: lithium hydroxide hydrate; water / acetonitrile / 20 °C 6.1: lithium hydroxide hydrate / 1,4-dioxane / 24 h / pH 9 7.1: sodium; ammonia / tetrahydrofuran / 1 h / -70 - -50 °C View Scheme