1: 2-nitro-5-hydroxy-1-fluorobenzene With sodium hydride in N,N-dimethyl-formamide; mineral oil 0.5 h; Cooling with ice; 2: chloromethyl methyl ether in N,N-dimethyl-formamide; mineral oil 1 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2371826 A1, 2011 ;
Location in patent: Page/Page column 50 ;
