(aS)-2-氯-alpha-[[2-(2-噻吩基)乙基]氨基]-苯乙酸甲酯合成路线 (共 3 条)
反应条件
sodium hydrogencarbonate; potassium iodide in acetonitrile 12 h; Reflux;
参考文献
Ferraboschi, Patrizia; Mieri, Maria De; Galimberti, Fiorella
Tetrahedron Asymmetry, 2010 , vol. 21, # 17 p. 2136 - 2141
反应条件
triethylamine T=78 - 82°C; 8 - 10 h; Product distribution / selectivity;
参考文献
WO2007/144729 A1, ;
Page/Page column 5; 8 ;
反应条件
1: in water T=60°C; 0.333333 - 0.5 h; 2: With sodium hydrogencarbonate in dichloromethane; water pH=7 - 8; Product distribution / selectivity;
参考文献
ORCHID CHEMICALS and PHARMACEUTICALS LIMITED
Patent: WO2007/144729 A1, 2007 ;
Location in patent: Page/Page column 5; 7-8 ;