(R)-2-(2,4-二氟苯基)-3-[1H-1,2,4]三唑-1-基丙烷-1,2-二醇合成路线 （共 21 条）
反应条件
methanol; sodium carbonate 15 h; Heating;
参考文献
Yasohara, Yoshihiko; Miyamoto, Kenji; Kizaki, Noriyuku; Hasegawa, Junzo; Ohashi, Takehisa
Tetrahedron Letters, 2001 , vol. 42, # 19 p. 3331 - 3333
反应条件
in water; ethyl acetate; N,N-dimethyl-formamide
参考文献
Schering Corporation
Patent: US5703236 A1, 1997 ;
反应条件
potassium carbonate in acetonitrile 3 h; Heating;
参考文献
Suzuki, Masato; Kato, Nobuki; Kanaki, Motomu; Shibasaki, Masakatsu
Organic Letters, 2005 , vol. 7, # 13 p. 2527 - 2530
反应条件
in diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide
参考文献
SCHERING CORPORATION
Patent: EP539938 A1, 1993 ;
反应条件
potassium carbonate in tetrahydrofuran Heating;
参考文献
Yasohara, Yoshihiko; Miyamoto, Kenji; Kizaki, Noriyuku; Hasegawa, Junzo; Ohashi, Takehisa
Tetrahedron Letters, 2001 , vol. 42, # 19 p. 3331 - 3333
反应条件
1: 97 percent / NaBH4 / tetrahydrofuran; H2O / 1.5 h / cooling 2: 74 percent / K2CO3 / acetonitrile / 3 h / Heating View Scheme
参考文献
Suzuki, Masato; Kato, Nobuki; Kanaki, Motomu; Shibasaki, Masakatsu
Organic Letters, 2005 , vol. 7, # 13 p. 2527 - 2530
反应条件
1: 98 percent / aq. HCl / tetrahydrofuran / 0.08 h / 20 °C 2: 97 percent / NaBH4 / tetrahydrofuran; H2O / 1.5 h / cooling 3: 74 percent / K2CO3 / acetonitrile / 3 h / Heating View Scheme
参考文献
Suzuki, Masato; Kato, Nobuki; Kanaki, Motomu; Shibasaki, Masakatsu
Organic Letters, 2005 , vol. 7, # 13 p. 2527 - 2530
反应条件
1: 87 percent / DIBALH / toluene / 2 h / -78 - -40 °C 2: 98 percent / aq. HCl / tetrahydrofuran / 0.08 h / 20 °C 3: 97 percent / NaBH4 / tetrahydrofuran; H2O / 1.5 h / cooling 4: 74 percent / K2CO3 / acetonitrile / 3 h / Heating View Scheme
参考文献
Suzuki, Masato; Kato, Nobuki; Kanaki, Motomu; Shibasaki, Masakatsu
Organic Letters, 2005 , vol. 7, # 13 p. 2527 - 2530
反应条件
1: (2S,3S,4R)-2-Ph2P(O)CH2-3-OH-4-(2-OH-4,5-F2-C6H2)tetraHpyran; Gd(HMDS)3; propionitrile / 3 h / -40 °C 2: 87 percent / DIBALH / toluene / 2 h / -78 - -40 °C 3: 98 percent / aq. HCl / tetrahydrofuran / 0.08 h / 20 °C 4: 97 percent / NaBH4 / tetrahydrofuran; H2O / 1.5 h / cooling 5: 74 percent / K2CO3 / acetonitrile / 3 h / Heating View Scheme
参考文献
Suzuki, Masato; Kato, Nobuki; Kanaki, Motomu; Shibasaki, Masakatsu
Organic Letters, 2005 , vol. 7, # 13 p. 2527 - 2530
反应条件
1.1: magnesium / tetrahydrofuran / 1 h / 5 °C 1.2: tetrahydrofuran / 1 h / 5 °C 2.1: 90 percent / lipase D; methylcyclohexane; aq. NaOH / 18 h / 15 °C / pH 5.5 3.1: 94 percent / pyridine / ethyl acetate / 30 °C 4.1: 60 percent / sodium carbonate; methanol / 15 h / Heating View Scheme
参考文献
Zhang, Yongqiang; Wang, Shengzheng; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian; Sheng, Chunquan
Chinese Journal of Chemistry, 2013 , vol. 31, # 9 p. 1139 - 1143
