(R)-2-(2,4-二氟苯基)-3-[1H-1,2,4]三唑-1-基丙烷-1,2-二醇合成路线 （共 21 条）
反应条件
1: 94 percent / pyridine / ethyl acetate / 30 °C 2: 60 percent / sodium carbonate; methanol / 15 h / Heating View Scheme
参考文献
Yasohara, Yoshihiko; Miyamoto, Kenji; Kizaki, Noriyuku; Hasegawa, Junzo; Ohashi, Takehisa
Tetrahedron Letters, 2001 , vol. 42, # 19 p. 3331 - 3333
反应条件
1: 90 percent / lipase D; methylcyclohexane; aq. NaOH / 18 h / 15 °C / pH 5.5 2: 94 percent / pyridine / ethyl acetate / 30 °C 3: 60 percent / sodium carbonate; methanol / 15 h / Heating View Scheme
参考文献
Yasohara, Yoshihiko; Miyamoto, Kenji; Kizaki, Noriyuku; Hasegawa, Junzo; Ohashi, Takehisa
Tetrahedron Letters, 2001 , vol. 42, # 19 p. 3331 - 3333
反应条件
1: 88 percent / aq. KOH / toluene / 20 °C 2: 40 percent / K2CO3 / tetrahydrofuran / Heating View Scheme
参考文献
Yasohara, Yoshihiko; Miyamoto, Kenji; Kizaki, Noriyuku; Hasegawa, Junzo; Ohashi, Takehisa
Tetrahedron Letters, 2001 , vol. 42, # 19 p. 3331 - 3333
反应条件
1: NaOH 2: 95 percent / DMAP / CH2Cl2 3: 95 percent / NaH / dimethylformamide / 0.5 h / Ambient temperature 4: 75 percent / HCOOH, H2O / 18 h / Heating View Scheme
参考文献
Lovey, Raymond G.; Saksena, Anil K.; Girijavallabhan, Viyyoor M.
Tetrahedron Letters, 1994 , vol. 35, # 33 p. 6047 - 6050
反应条件
1: 95 percent / NaH / dimethylformamide / 0.5 h / Ambient temperature 2: 75 percent / HCOOH, H2O / 18 h / Heating View Scheme
参考文献
Lovey, Raymond G.; Saksena, Anil K.; Girijavallabhan, Viyyoor M.
Tetrahedron Letters, 1994 , vol. 35, # 33 p. 6047 - 6050
反应条件
1: 95 percent / DMAP / CH2Cl2 2: 95 percent / NaH / dimethylformamide / 0.5 h / Ambient temperature 3: 75 percent / HCOOH, H2O / 18 h / Heating View Scheme
参考文献
Lovey, Raymond G.; Saksena, Anil K.; Girijavallabhan, Viyyoor M.
Tetrahedron Letters, 1994 , vol. 35, # 33 p. 6047 - 6050
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 2: Rongalit; sodium hydroxide / 1,4-dioxane / 0.5 h / 55 - 60 °C / |Inert atmosphere 3: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; tert.-butylhydroperoxide / dichloromethane; n-heptane / 8 h / -20 °C / |Inert atmosphere 4: potassium carbonate / tetrahydrofuran / 48 h / |Reflux View Scheme
参考文献
Zhang, Yongqiang; Wang, Shengzheng; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian; Sheng, Chunquan
Chinese Journal of Chemistry, 2013 , vol. 31, # 9 p. 1139 - 1143
反应条件
1: Rongalit; sodium hydroxide / 1,4-dioxane / 0.5 h / 55 - 60 °C / |Inert atmosphere 2: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; tert.-butylhydroperoxide / dichloromethane; n-heptane / 8 h / -20 °C / |Inert atmosphere 3: potassium carbonate / tetrahydrofuran / 48 h / |Reflux View Scheme
参考文献
Zhang, Yongqiang; Wang, Shengzheng; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian; Sheng, Chunquan
Chinese Journal of Chemistry, 2013 , vol. 31, # 9 p. 1139 - 1143
反应条件
1: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; tert.-butylhydroperoxide / dichloromethane; n-heptane / 8 h / -20 °C / |Inert atmosphere 2: potassium carbonate / tetrahydrofuran / 48 h / |Reflux View Scheme
参考文献
Zhang, Yongqiang; Wang, Shengzheng; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian; Sheng, Chunquan
Chinese Journal of Chemistry, 2013 , vol. 31, # 9 p. 1139 - 1143
反应条件
1: 75 percent / HCOOH, H2O / 18 h / Heating View Scheme
参考文献
Lovey, Raymond G.; Saksena, Anil K.; Girijavallabhan, Viyyoor M.
Tetrahedron Letters, 1994 , vol. 35, # 33 p. 6047 - 6050
