2-((叔丁氧基羰基)氨基)-2-苯乙酸甲酯合成路线 （共 38 条）
反应条件
lithium borohydride in ethanol Yield given;
参考文献
Matsunaga, Nobuyuki; Harada, Hiroshi; Aoyama, Toyohiko; Shioiri, Takayuki
Heterocycles, 1992 , vol. 33, # 1 p. 235 - 255
反应条件
lithium borohydride in ethanol Yield given;
参考文献
Matsunaga, Nobuyuki; Harada, Hiroshi; Aoyama, Toyohiko; Shioiri, Takayuki
Heterocycles, 1992 , vol. 33, # 1 p. 235 - 255
反应条件
lithium borohydride in ethanol Yield given;
参考文献
Matsunaga, Nobuyuki; Harada, Hiroshi; Aoyama, Toyohiko; Shioiri, Takayuki
Heterocycles, 1992 , vol. 33, # 1 p. 235 - 255
反应条件
1: 75 percent / tetrahydrofuran; diethyl ether / 30 h / Ambient temperature 2: 84 percent / t-BuOK / tetrahydrofuran / 0.5 h / 0 °C View Scheme
参考文献
Bull, Steven D.; Davies, Stephen G.; Jones, Simon; Sanganee, Hitesh J.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 4 p. 387 - 398
反应条件
1: 1.) Mg / 1.) THF, reflux, 2.) THF, r.t., 48 h 2: 81 percent / t-BuOK / tetrahydrofuran / 0.5 h / 0 °C View Scheme
参考文献
Bull, Steven D.; Davies, Stephen G.; Jones, Simon; Sanganee, Hitesh J.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 4 p. 387 - 398
反应条件
sodium hydrogencarbonate in ethanol
T=20°C; 16 h;
参考文献
AMGEN INC.; BREGMAN, Howard; BUCHANAN, John, L.; CHAKKA, Nagasree; DIMAURO, Erin; GUNAYDIN, Hakan; GUZMAN PEREZ, Angel; HUA, Zihao; HUANG, Hongbing; HUANG, Xin; MARTIN, Matthew, W.; PATEL, Vinod
Patent: WO2013/134079 A1, 2013 ;
Location in patent: Paragraph 0429-0430 ;
反应条件
triethylamine in tetrahydrofuran
T=20°C; 2 h;
参考文献
Armstrong, Alan; Edmonds, Ian D.; Swarbrick, Martin E.; Treweeke, Nigel R.
Tetrahedron, 2005 , vol. 61, # 35 p. 8423 - 8442
反应条件
triethylamine in methanol
T=20°C; Acylation; 24 h;
参考文献
Yuste, Francisco; Ortiz, Benjamin; Carrasco, Alejandra; Peralta, Martha; Quintero, Leticia; Sanchez-Obregon, Ruben; Walls, Fernando; Garcia Ruano, Jose L.
Tetrahedron Asymmetry, 2000 , vol. 11, # 15 p. 3079 - 3090
反应条件
polymethylhydrosiloxane; palladium on activated charcoal in ethanol
T=20°C; Carboxylation; 5 h;
参考文献
Chandrasekhar; Chandraiah; Raji Reddy; Venkat Reddy
Chemistry Letters, 2000 , # 7 p. 780 - 781
反应条件
1: formic acid / methanol; H2O / 72 h / 20 °C
2: anhydrous potassium carbonate / tetrahydrofuran / 17 h / Heating
3: 81 percent / ethyldiisopropylamine; anhydrous zinc triflate; (-)-(1R,2S)-N-methylephedrine / molecular sieves 4 Angstroem / -20 °C
4: sodium nitrite; acetic acid / dimethylsulfoxide / 24 h / 40 °C
5: 135 mg / methanol; benzene / 0.33 h / 20 °C
View Scheme
参考文献
Palomo, Claudio; Oiarbide, Mikel; Halder, Rajkumar; Laso, Antonio; Lopez, Rosa
Angewandte Chemie - International Edition, 2006 , vol. 45, # 1 p. 117 - 120
