2-((叔丁氧基羰基)氨基)-2-苯乙酸甲酯合成路线 （共 38 条）
反应条件
1: formic acid / methanol; H2O / 72 h / 20 °C
2: anhydrous potassium carbonate / tetrahydrofuran / 17 h / Heating
3: 81 percent / ethyldiisopropylamine; anhydrous zinc triflate; (-)-(1R,2S)-N-methylephedrine / molecular sieves 4 Angstroem / -20 °C
4: sodium nitrite; acetic acid / dimethylsulfoxide / 24 h / 40 °C
5: 135 mg / methanol; benzene / 0.33 h / 20 °C
View Scheme
参考文献
Palomo, Claudio; Oiarbide, Mikel; Halder, Rajkumar; Laso, Antonio; Lopez, Rosa
Angewandte Chemie - International Edition, 2006 , vol. 45, # 1 p. 117 - 120
反应条件
1: 81 percent / ethyldiisopropylamine; anhydrous zinc triflate; (-)-(1R,2S)-N-methylephedrine / molecular sieves 4 Angstroem / -20 °C
2: sodium nitrite; acetic acid / dimethylsulfoxide / 24 h / 40 °C
3: 135 mg / methanol; benzene / 0.33 h / 20 °C
View Scheme
参考文献
Palomo, Claudio; Oiarbide, Mikel; Halder, Rajkumar; Laso, Antonio; Lopez, Rosa
Angewandte Chemie - International Edition, 2006 , vol. 45, # 1 p. 117 - 120
反应条件
1: anhydrous potassium carbonate / tetrahydrofuran / 17 h / Heating
2: 81 percent / ethyldiisopropylamine; anhydrous zinc triflate; (-)-(1R,2S)-N-methylephedrine / molecular sieves 4 Angstroem / -20 °C
3: sodium nitrite; acetic acid / dimethylsulfoxide / 24 h / 40 °C
4: 135 mg / methanol; benzene / 0.33 h / 20 °C
View Scheme
参考文献
Palomo, Claudio; Oiarbide, Mikel; Halder, Rajkumar; Laso, Antonio; Lopez, Rosa
Angewandte Chemie - International Edition, 2006 , vol. 45, # 1 p. 117 - 120
反应条件
in methanol
T=20°C; 1 h;
参考文献
Aerie Pharmaceuticals, Inc.
Patent: US2009/186917 A1, 2009 ;
Location in patent: Page/Page column 11 ;
US 20090186917 A1
反应条件
Rh2(triphenylacetate)4; (R)-6,6'-di(naphthalen-2-yl)-1,1'-spirobiindanyl-7,7'-diyl hydrogenphosphate in chloroform
T=25°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Xu, Bin; Zhu, Shou-Fei; Xie, Xiu-Lan; Shen, Jun-Jie; Zhou, Qi-Lin
Angewandte Chemie - International Edition, 2011 , vol. 50, # 48 p. 11483 - 11486
反应条件
1: sodium nitrite; acetic acid / dimethylsulfoxide / 24 h / 40 °C
2: 135 mg / methanol; benzene / 0.33 h / 20 °C
View Scheme
参考文献
Palomo, Claudio; Oiarbide, Mikel; Halder, Rajkumar; Laso, Antonio; Lopez, Rosa
Angewandte Chemie - International Edition, 2006 , vol. 45, # 1 p. 117 - 120
反应条件
1: 77 percent / ZnBr2 / diethyl ether
2: 100 percent / pyridine / CH2Cl2 / Ambient temperature
3: p-toluenesulfonic acid monohydrate / methanol / 4 h / Heating
4: 1.) NaIO4, aq. NaHCO3, 2.) NaClO2, NaH2PO4 / 1.) CH2Cl2, room temp., 2 h, 2.) CH3CN, H2O, 10 deg C, 2 h
5: diethyl ether
6: 96 percent / H2 / Pd(OH)2/C / methanol
View Scheme
参考文献
Merino, Pedro; Castillo, Elena; Franco, Santiago; Merchan, Francisco L.; Tejero, Tomas
Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2371 - 2374
反应条件
1: 100 percent / pyridine / CH2Cl2 / Ambient temperature
2: p-toluenesulfonic acid monohydrate / methanol / 4 h / Heating
3: 1.) NaIO4, aq. NaHCO3, 2.) NaClO2, NaH2PO4 / 1.) CH2Cl2, room temp., 2 h, 2.) CH3CN, H2O, 10 deg C, 2 h
4: diethyl ether
5: 96 percent / H2 / Pd(OH)2/C / methanol
View Scheme
参考文献
Merino, Pedro; Castillo, Elena; Franco, Santiago; Merchan, Francisco L.; Tejero, Tomas
Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2371 - 2374
反应条件
1: p-toluenesulfonic acid monohydrate / methanol / 4 h / Heating
2: 1.) NaIO4, aq. NaHCO3, 2.) NaClO2, NaH2PO4 / 1.) CH2Cl2, room temp., 2 h, 2.) CH3CN, H2O, 10 deg C, 2 h
3: diethyl ether
4: 96 percent / H2 / Pd(OH)2/C / methanol
View Scheme
参考文献
Merino, Pedro; Castillo, Elena; Franco, Santiago; Merchan, Francisco L.; Tejero, Tomas
Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2371 - 2374
反应条件
in methanol; benzene
T=20°C; 0.333333 h;
参考文献
Palomo, Claudio; Oiarbide, Mikel; Halder, Rajkumar; Laso, Antonio; Lopez, Rosa
Angewandte Chemie - International Edition, 2006 , vol. 45, # 1 p. 117 - 120
