2-((叔丁氧基羰基)氨基)-2-苯乙酸甲酯合成路线 （共 38 条）
反应条件
1: 1.) NaIO4, aq. NaHCO3, 2.) NaClO2, NaH2PO4 / 1.) CH2Cl2, room temp., 2 h, 2.) CH3CN, H2O, 10 deg C, 2 h
2: diethyl ether
3: 96 percent / H2 / Pd(OH)2/C / methanol
View Scheme
参考文献
Merino, Pedro; Castillo, Elena; Franco, Santiago; Merchan, Francisco L.; Tejero, Tomas
Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2371 - 2374
反应条件
1: NaClO2, NaH2PO4, aq. H2O2 / acetonitrile
2: diethyl ether
3: 96 percent / H2 / Pd(OH)2/C / methanol
View Scheme
参考文献
Merino, Pedro; Castillo, Elena; Franco, Santiago; Merchan, Francisco L.; Tejero, Tomas
Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2371 - 2374
反应条件
Rh2(triphenylacetate)4; (R)-6,6'-di(naphthalen-2-yl)-1,1'-spirobiindanyl-7,7'-diyl hydrogenphosphate in chloroform
T=25°C; 0.0166667 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Xu, Bin; Zhu, Shou-Fei; Xie, Xiu-Lan; Shen, Jun-Jie; Zhou, Qi-Lin
Angewandte Chemie - International Edition, 2011 , vol. 50, # 48 p. 11483 - 11486
参考文献
Matsunaga, Hirofumi; Ishizuka, Tadao; Kunieda, Takehisa
Tetrahedron, 1997 , vol. 53, # 4 p. 1275 - 1294
反应条件
1.1: K2CO3 / H2O / 2 h / 100 °C
1.2: dioxane / 24 h / 20 °C
2.1: diethyl ether
View Scheme
参考文献
Yokoyama; Hikawa; Murakami
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 12 p. 1431 - 1434
反应条件
1.1: K2CO3 / H2O / 2 h / 100 °C
1.2: dioxane / 24 h / 20 °C
2.1: diethyl ether
View Scheme
参考文献
Yokoyama; Hikawa; Murakami
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 12 p. 1431 - 1434
反应条件
1: SOCl2 / 20 °C
2: acetonitrile / 20 °C
View Scheme
参考文献
Tohma; Endo; Kan; Fukuyama
Synlett, 2001 , # 7 p. 1179 - 1181
反应条件
1: pyridinium dichromate / dimethylformamide / 6 h / Ambient temperature
View Scheme
参考文献
Matsunaga, Hirofumi; Ishizuka, Tadao; Kunieda, Takehisa
Tetrahedron, 1997 , vol. 53, # 4 p. 1275 - 1294
反应条件
1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Reflux; Inert atmosphere
2: titanium tetrachloride; triethylamine / toluene / 12 h / 0 - 20 °C / Inert atmosphere
3: (R)-N-(phenylcarbamoyl)-tert-butanesulfinamide; trichlorosilane; water / acetonitrile / 24 h / -40 °C
4: ammonium cerium (IV) nitrate; water / acetonitrile / 0.5 h / 0 °C
5: acetonitrile / 12 h / 20 °C
6: acetic acid; sodium nitrite / dimethyl sulfoxide / 24 h / 40 °C / Inert atmosphere
7: diethyl ether / 0.5 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Liu, Xiang-Wei; Yan, Yan; Wang, Yong-Qiang; Wang, Chao; Sun, Jian
Chemistry - A European Journal, 2012 , vol. 18, # 30 p. 9204 - 9207
反应条件
1: titanium tetrachloride; triethylamine / toluene / 12 h / 0 - 20 °C / Inert atmosphere
2: (R)-N-(phenylcarbamoyl)-tert-butanesulfinamide; trichlorosilane; water / acetonitrile / 24 h / -40 °C
3: ammonium cerium (IV) nitrate; water / acetonitrile / 0.5 h / 0 °C
4: acetonitrile / 12 h / 20 °C
5: acetic acid; sodium nitrite / dimethyl sulfoxide / 24 h / 40 °C / Inert atmosphere
6: diethyl ether / 0.5 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Liu, Xiang-Wei; Yan, Yan; Wang, Yong-Qiang; Wang, Chao; Sun, Jian
Chemistry - A European Journal, 2012 , vol. 18, # 30 p. 9204 - 9207
