5-[[4-[3-(5-甲基-2-苯基-1,3-恶唑-4-基)丙酰]苯基]甲基]-1,3-噻唑烷-2,4-二酮合成路线 （共 2 条）
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran P=2585.7 Torr; 24 h; Ambient temperature;
参考文献
Hulin, Bernard; Clark, David A.; Goldstein, Steven W.; McDermott, Ruth E.; Dambek, Paul J.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1853 - 1864
反应条件
1: 98 percent / diethyl ether / -75 °C 2: 60 percent / manganese dioxide / toluene / 18 h / Heating 3: 1.) sodium hydride / 1.) ether, RT, 25 min, 2.) ether, ethanol, reflux, 6 h 4: 1.) sodium hydride / 1.) THF, RT, 0.5 h, 2.) THF, reflux, 48 h 5: conc. HCl / acetic acid / 5 h / Heating 6: 71 percent / piperidine / ethanol / 24 h / Heating 7: 81 percent / H2 / Pd/C / tetrahydrofuran / 24 h / 2585.7 Torr / Ambient temperature View Scheme
参考文献
Hulin, Bernard; Clark, David A.; Goldstein, Steven W.; McDermott, Ruth E.; Dambek, Paul J.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1853 - 1864
