water in acetonitrile T=70°C;

Amberlyst 15 in tetrahydrofuran; water Ambient temperature;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1) NaNH₂, 2) NH₄Cl / liq. NH₃, Et₂O<br />2: 1) BuLi, hexamethylphosphoric triamide (HMPA), 2) HMPA / 1) THF, -70 deg C, 2) THF, -70 to rt, 2 h<br /> <br /> &nbsp;