2-氧代-2,5-二氢-吡咯-1-羧酸叔丁酯合成路线 （共 11 条）
反应条件
N,N-dimethyl-N-(4'-methylphenyl)amine N-oxide in dichloromethane T=20°C; 4 h;
参考文献
Zhu, Chen; Wang, Rui; Falck
Organic Letters, 2012 , vol. 14, # 13 p. 3494 - 3497
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile 0.5 h; Ambient temperature;
参考文献
Casiraghi, Giovanni; Rassu, Gloria; Spanu, Pietro; Pinna, Luigi
Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3760 - 3763
反应条件
1: pyrrole With dihydrogen peroxide; barium carbonate in water 3 h; Heating; 2: di-tert-butyl dicarbonate With 4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C; 45 h;
参考文献
Macdonald, Simon J.F.; Inglis, Graham G.A.; Bentley, Deborah; Dowle, Michael D.
Tetrahedron Letters, 2002 , vol. 43, # 29 p. 5057 - 5060
反应条件
hexafluoroisopropyl alcohol; scandium tris(trifluoromethanesulfonate) in dichloromethane T=-25°C; Michael addition; 18 h; Product distribution; Further Variations:CatalystsTemperatures;
参考文献
Heterocycles, , vol. 71, # 2 p. 361 - 371
反应条件
methanesulfonyl chloride; triethylamine in tetrahydrofuran T=0 - 20°C; 4.5 h; Inert atmosphereLarge scale;
参考文献
Organic Process Research and Development, , vol. 6, # 4 p. 416 - 418
反应条件
1: 76 percent / DMAP / tetrahydrofuran 2: 35 percent / (PCy3)2RuCl2(CHC6H5) / CH2Cl2 / Heating View Scheme
参考文献
Synthetic Communications, , vol. 33, # 2 p. 223 - 228
反应条件
1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 °C 1.2: 68 percent / tetrahydrofuran; hexane / 0.25 h / -78 °C 2.1: 69 percent / pyridine; hydrogen peroxide / H2O; CH2Cl2 / 2 h / -78 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 52 p. 12252 - 12263
参考文献
Synthetic Communications, , vol. 36, # 15 p. 2253 - 2257
反应条件
1: 90 percent / 2,6-lutidine / CH2Cl2 / 0.75 h / Ambient temperature 2: 78 percent / SnCl4 / diethyl ether / 3 h / -85 °C 3: 90 percent / H2, AcONa / 10percent Pd/C / tetrahydrofuran / 24 h / Ambient temperature 4: 80percent aq. acetic acid / 8 h / 50 °C 5: 60 percent / aq. NaIO4, SiO2 / CH2Cl2 / 0.25 h 6: NaBH4 / methanol / 2 h / -30 - 0 °C View Scheme
参考文献
Rassu, Gloria; Zanardi, Franca; Battistini, Lucia; Gaetani, Enrico; Casiraghi, Giovanni
Journal of Medicinal Chemistry, 1997 , vol. 40, # 2 p. 168 - 180
反应条件
n-butyllithium; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex 1.) Et2O, hexane, THF, -78 deg C, 1 h, 2.) THF, Et2O, hexane, -78 deg C, 1.5 h; Yield given. Multistep reaction;
参考文献
Diaz, Adolfo; Siro, Jorge G.; Garcia-Navio, Jose L.; Vaquero, Juan J.; Alvarez-Builla, Julio
Synthesis, 1997 , # 5 p. 559 - 562
