反应条件
1.1: sodium hydrogencarbonate; sodium hypochlorite; potassium bromide; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / anhydrous difluoromethane / 25 °C / Cooling with ice 2.1: (R)-2,2'-dihydroxy-1,1'-binaphthyl / titanium(IV) isopropylate / diethyl ether; tetrahydrofuran / 1.5 h / 0 - 25 °C 2.2: -20 - 25 °C 2.3: 0 °C View Scheme
参考文献
PHARMATHEN S.A.; KOFTIS, Theocharis V.; ANDREOU, Thanos; GIOTI, Efthimia; ZITROU, Asteria
Patent: WO2012/155932 A1, 2012 ;