hydrogenchloride T=70°C; 12 h;

1: 85 percent / Ti(OiPr)4, 2-OH-3,5-Cl2-C6H4-CH=(t-Leu-Thr(OtBu)-Gly-OMe), iPrOH / toluene / 20 h / 4 °C 2: 6N HCl / 12 h / 70 °C View Scheme

1: in water pH=7; 2: pH=7;

chymotripsin pH=7.5; 4 h; aq. bufferResolution of racemate; optical yield given as percent ee;

1: 2-(2-thienyl)ethanol benzenesulfonate; (S)-α-amino-(2-chlorophenyl)acetic acid With sodium hydrogencarbonate in anhydrous propionitrile Heating; 2: formaldehyd With formic acid T=40°C; 3 h; 3: With sodium hydroxide in dichloromethane; water T=0°C; pH=~ 6; Product distribution / selectivity;