1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 85 °C / |Inert atmosphere 2: lithium hydroxide hydrate / THF-d8 (tetrahydrofuran-d8); methanol / 20 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4267587', constants.ctx, '0')">potassium carbonate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=85&deg;C;&nbsp;28&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;&nbsp;regioselective reaction;&nbsp;<br /> &nbsp;