1.1: diethylamine; n-butyllithium / tetrahydrofuran / -78 °C 1.2: -78 - 23 °C 2.1: cesium fluoride View Scheme

1.1: diethylamine; n-butyllithium / tetrahydrofuran / -78 °C 1.2: -78 - 23 °C 2.1: cesium fluoride View Scheme

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '23167013', constants.ctx, '0')">C₉H₁₂N₂O₂</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1732991', constants.ctx, '0')">N,N,N',N,-tetramethylethylenediamine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '2370068', constants.ctx, '0')">t-butyldimethylsiyl triflate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br />T=-78 - 23&deg;C;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '1209232', constants.ctx, '0')">chloro-trimethyl-silane</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1732991', constants.ctx, '0')">N,N,N',N,-tetramethylethylenediamine</a> <br />T=-78&deg;C;&nbsp;<br />Stage #3: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '906717', constants.ctx, '0')">lithium diisopropyl amide</a> <br />T=-78&deg;C;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: triethylamine / dichloromethane<br />2.1: N,N,N',N,-tetramethylethylenediamine; t-butyldimethylsiyl triflate / tetrahydrofuran; diethyl ether / -78 - 23 &deg;C<br />2.2: -78 &deg;C<br />2.3: -78 &deg;C<br /> <br /> &nbsp;