(R)-[1-[[[(4-甲基苯基)磺酰基]氧基]甲基]-2-苯基乙基]氨基甲酸1,1-二甲基乙酯合成路线 （共 22 条）
反应条件
1: 4-methyl-morpholine 2: sodium tetrahydroborate 3: 4-(N,N-dimethlyamino)pyridine; triethylamine View Scheme
参考文献
Journal of Peptide Science, , vol. 17, # 7 p. 527 - 532
反应条件
1: sodium tetrahydroborate 2: 4-(N,N-dimethlyamino)pyridine; triethylamine View Scheme
参考文献
Journal of Peptide Science, , vol. 17, # 7 p. 527 - 532
反应条件
1: 82 percent / pyridine / dimethylformamide / 60 h / 23 °C 2: trifluoroacetic acid / CH2Cl2 / 23 °C View Scheme
参考文献
Christoffers, Jens; Mann, Alexander
Angewandte Chemie - International Edition, 2000 , vol. 39, # 15 p. 2752 - 2754
反应条件
1: LiAlH4 / tetrahydrofuran / 4 h / Heating 2: 72 percent / anhydrous potassium carbonate / acetonitrile / 12 h / 25 °C View Scheme
参考文献
Tetrahedron, , vol. 63, # 39 p. 9758 - 9763
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 4 h; Heating;
参考文献
Talluri, Siva Kumar; Sudalai, Arumugam
Tetrahedron, 2007 , vol. 63, # 39 p. 9758 - 9763
反应条件
sodium hydroxide; dihydrogen peroxide in methanol; water 2 h;
参考文献
Tetrahedron Letters, , vol. 40, # 13 p. 2629 - 2632
反应条件
sodium iodide in acetone T=20°C; 24 h;
参考文献
Ohno; Anzai; Toda; Ohishi; Fujii; Tanaka; Takemoto; Ibuka
Journal of Organic Chemistry, 2001 , vol. 66, # 14 p. 4904 - 4914
反应条件
1: dimethylformamide / 24 h / Ambient temperature 2: 6 M HCl / 12 h / Heating View Scheme
参考文献
Sutherland, Andrew; Willis, Christine L.
Journal of Organic Chemistry, 1998 , vol. 63, # 22 p. 7764 - 7769
反应条件
1: LiAlH4 / tetrahydrofuran / 4 h / Heating 2: 72 percent / anhydrous potassium carbonate / acetonitrile / 12 h / 25 °C View Scheme
参考文献
Tetrahedron, , vol. 63, # 39 p. 9758 - 9763
反应条件
1: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C 2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 1 h / 760.05 Torr View Scheme
参考文献
SEQUOIA PHARMACEUTICALS, INC.
Patent: WO2009/105782 A1, 2009 ;
WO 2009/105782 A1
