2,5-二氟-4-硝基甲苯合成路线 （共 3 条）
反应条件
nitric acid T=0 - 10°C; 0.5 h;
参考文献
Thornton; Jackman; Marsham; O'Connor; Bishop; Calvert
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2321 - 2327
反应条件
sodium dichromate; sulfuric acid; acetic acid
参考文献
Thornton; Jackman; Marsham; O'Connor; Bishop; Calvert
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2321 - 2327
反应条件
1: 85 percent / Na2Cr2O7, AcOH, conc. H2SO4
2: oxalyl chloride, DMF / CH2Cl2 / 2.5 h
3: 100 percent / Et3N / CH2Cl2 / 1 h
View Scheme
参考文献
Thornton; Jackman; Marsham; O'Connor; Bishop; Calvert
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2321 - 2327
