2,3-二氟-6-硝基苯乙酸合成路线 （共 5 条）
反应条件
sulfuric acid; nitric acid in water T=-10 - -5°C; 0.25 h;
参考文献
US2006/30609 A1, ;
Page/Page column 17 ;
反应条件
hydrogenchloride in water
参考文献
WO2007/36715 A2, ;
Page/Page column 48 ;
WO 2007/036715 A2
反应条件
1: 2: With hydrogenchloride; acetic acid 14 h; Heating; Further stages.;
参考文献
Lee, Lily; Kreutter, Kevin D.; Pan, Wenxi; Crysler, Carl; Spurlino, John; Player, Mark R.; Tomczuk, Bruce; Lu, Tianbao
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 22 p. 6266 - 6269
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50°C; 0.5 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/36715 A2, 2007 ;
Location in patent: Page/Page column 48-49 ;
WO 2007/036715 A2
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=50°C; 0.5 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/36715 A2, 2007 ;
Location in patent: Page/Page column 48-49 ;
WO 2007/036715 A2
