1,5-脱水-L-山梨糖醇合成路线 （共 6 条）
反应条件
sodium tetrahydroborate; cation-exchange resin in water T=5°C; 12 h;
参考文献
Dromowicz, Manfred; Koell, Peter
Carbohydrate Research, 1998 , vol. 311, # 3 p. 103 - 119
反应条件
sodium methylate in methanol T=45°C; 0.333333 h;
参考文献
Malmberg, Jesper; Mani, Katrin; Saewen, Elin; Wiren, Anders; Ellervik, Ulf
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 19 p. 6659 - 6665
反应条件
1.1: Bu3SnH; 2,2'-azobis(isobutyronitrile) / diethyl ether / 0.5 h / 20 °C 1.2: 0.844 g / KF / H2O / 0.33 h / 20 °C 2.1: 95 percent / NaOMe / methanol / 0.33 h / 45 °C View Scheme
参考文献
Malmberg, Jesper; Mani, Katrin; Saewen, Elin; Wiren, Anders; Ellervik, Ulf
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 19 p. 6659 - 6665
反应条件
1.1: HBr; AcOH; Ac2O / 1.5 h / 20 °C 2.1: Bu3SnH; 2,2'-azobis(isobutyronitrile) / diethyl ether / 0.5 h / 20 °C 2.2: 0.844 g / KF / H2O / 0.33 h / 20 °C 3.1: 95 percent / NaOMe / methanol / 0.33 h / 45 °C View Scheme
参考文献
Malmberg, Jesper; Mani, Katrin; Saewen, Elin; Wiren, Anders; Ellervik, Ulf
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 19 p. 6659 - 6665
反应条件
1: 1.) 30percent H2O2, K2CO3 / 1.) H2O, 20 deg C, 48 h; 2.) reflux, 36 h 2: 90 percent / NaBH4, cation-exchange resin / H2O / 12 h / 5 °C View Scheme
参考文献
Dromowicz, Manfred; Koell, Peter
Carbohydrate Research, 1998 , vol. 311, # 3 p. 103 - 119
反应条件
1: 91 percent / 1M NaOMe / methanol / 1 h / 20 °C 2: 90 percent / NaBH4, cation-exchange resin / H2O / 12 h / 5 °C View Scheme
参考文献
Dromowicz, Manfred; Koell, Peter
Carbohydrate Research, 1998 , vol. 311, # 3 p. 103 - 119
