sodium hydroxide in water T=20°C; 1.16667 h;

1: 2-methylpropan-2-yl 4-(acetyloxy)piperidine-1-carboxylate With trifluoroacetic acid in dichloromethane T=20°C; 3 h; 2: With triethylamine in dichloromethane T=0 - 20°C; 3: methanesulfonyl chloride in dichloromethane T=0 - 20°C; 15 h;

1: 4-hydroxy-1-methylsulfonylpiperidine With sodium hydride in DMF (N,N-dimethyl-formamide) T=20°C; 0.333333 h; 2: 1-Bromo-2-butyne in DMF (N,N-dimethyl-formamide) T=20°C; 20 h;

1: 4-hydroxy-1-methylsulfonylpiperidine With sodium hydride in DMF (N,N-dimethyl-formamide) T=20°C; 0.333333 h; 2: 4-(bromomethyl)-2,6-dimethylpyridine in tetrahydrofuran; DMF (N,N-dimethyl-formamide) T=20°C; 120 h;