1: 98 percent / 0.25 N aq. HCl / methanol / 1.5 h / Ambient temperature 2: 83 percent / 6 N aq. HCl / 1 h / Heating 3: 87 percent / H2O / Raney Ni / ethanol / 8 h / Heating View Scheme

<b>Multi-step reaction with 5 steps<br /> </b>1: 96 percent / active γ-MnO₂ / CHCl₃ / 1 h / Heating<br />2: 73 percent / NaH / dimethylformamide / 3 h / 120 &deg;C<br />3: 97 percent / NaBH₄ / methanol / 0.5 h / Ambient temperature<br />4: 97 percent / SOCl₂ / 1.) 0 deg C, 30 min, 2.) RT, 30 min<br />5: 1.) butyllithium / 1.) hexane, THF, -78 deg C, 15 min, 2.)a) hexane, THF, -78 deg C, 1 h, b) -50 deg C, 18 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 73 percent / NaH / dimethylformamide / 3 h / 120 &deg;C<br />2: 97 percent / NaBH₄ / methanol / 0.5 h / Ambient temperature<br />3: 97 percent / SOCl₂ / 1.) 0 deg C, 30 min, 2.) RT, 30 min<br />4: 1.) butyllithium / 1.) hexane, THF, -78 deg C, 15 min, 2.)a) hexane, THF, -78 deg C, 1 h, b) -50 deg C, 18 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 73 percent / NaH / dimethylformamide / 3 h / 120 &deg;C<br />2: 97 percent / NaBH₄ / methanol / 0.5 h / Ambient temperature<br />3: SOCl₂ / 1 h / 0 - 20 &deg;C<br />4: 70 percent / tetrahydrofuran / 18 h / -50 &deg;C<br /> <br /> &nbsp;