1.1: potassium carbonate / acetonitrile / 1.17 h / 25 - 60 °C 1.2: 16 h / 25 - 75 °C 2.1: hydrogenchloride / water / 2 h / 75 - 80 °C View Scheme

1: 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole monohydrochloride With potassium carbonate in acetonitrile T=25 - 60°C; 1.16667 h; 2: 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one palmitate ester With tetrabutylammomium bromide; potassium iodide T=20 - 75°C; 14 h;