3-二氟甲基-1-甲基吡唑-4-甲酸乙酯合成路线 （共 42 条）
反应条件
in acetonitrile T=20°C; 1.08333 h;
参考文献
US2011/9642 A1, ;
Page/Page column 9 ;
反应条件
1: methylhydrazine in acetone T=10 - 20°C; 1 h; 2: 2-ethoxymethlene-4,4-difluoroacetoacetic acid ethyl ester in acetone T=20°C; 3 h;
参考文献
US2011/28735 A1, ;
Page/Page column 5 ;
反应条件
1: 3-(dimethylamino)acrylic acid ethyl ester; difluoroacetic acid fluoride in toluene T=0 - 3°C; 2: 2-(difluoroacetyl)-3-(dimethylamino)-acrylic acid ethyl ester; methylhydrazine in toluene T=-20 - 25°C;
参考文献
US2010/204483 A1, ;
Page/Page column 5 ;
反应条件
methanesulfonic acid in toluene T=50°C; Product distribution / selectivity;
参考文献
WO2011/54733 A1, ;
Page/Page column 37-38 ;
反应条件
toluene-4-sulfonic acid in N,N-dimethyl-formamide T=50 - 110°C;
参考文献
EP2008996 A1, ;
Page/Page column 16 ;
反应条件
sodium hydroxide in ethanol; water; toluene T=-3 - 20°C; 3 h;
参考文献
US2011/40096 A1, ;
Page/Page column 10 ;
反应条件
1: N,N'-dibenzylidene-N-methylhydrazinium methylsulfate With sodium hydroxide in water; toluene T=60°C; 3 h; 2: 2-ethoxymethlene-4,4-difluoroacetoacetic acid ethyl ester With toluene-4-sulfonic acid in toluene T=20 - 60°C;
参考文献
US2012/220781 A1, ;
Page/Page column 13 ;
参考文献
WO2006/45504 A1, ;
Page/Page column 4 ;
反应条件
anhydrous tetramethylammonium chloride; sodium hydroxide in water; toluene T=15°C; pH=10.8 - 11; Product distribution / selectivity;
参考文献
WO2011/12620 A2, ;
Page/Page column 16 ;
反应条件
5 palladium on charcoal; hydrogen; trioctylmethylammonium chloride; potassium carbonate; cesium fluoride in tetrahydrofuran T=110°C; pH=11; 20 h; Autoclave; Reagent/catalyst;
参考文献
EP2687514 A1, ;
Paragraph 0049; 0050 ;
