3-(二氟甲基)-1-甲基-1H-吡唑-4-羰酰氯合成路线 （共 6 条）
反应条件
thionyl chloride in chlorobenzene T=110°C; 3 h;
参考文献
WO2007/31323 A1, ;
Page/Page column 27 ;
反应条件
in toluene; xylene T=10 - 95°C; P=150.015 Torr;
参考文献
US2011/54183 A1, ;
Page/Page column 4 ;
反应条件
in toluene T=25 - 85°C; P=300.03 Torr;
参考文献
BASF SE
Patent: US2011/54183 A1, 2011 ;
Location in patent: Page/Page column 4 ;
反应条件
1: With triethylamine in 1,4-dioxane T=25 - 82°C; 3 h; 2: With sodium hydroxide in tert-butyl methyl ether; water 0.5 h; 3: With hydrogenchloride in tert-butyl methyl ether; water
参考文献
US2012/136162 A1, ;
Page/Page column 8 ;
反应条件
in toluene
T=0 - 85°C; P=300.03 Torr; Product distribution / selectivity;
参考文献
Jasch, Hannelore; Scheumann, Julia; Heinrich, Markus R.
Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10699 - 10706
反应条件
triethylamine in tetrahydrofuran
T=60°C; 16 h; Reflux;
参考文献
BASF SE; Heinrich, Markus; Pratsch, Gerald
Patent: US2013/338369 A1, 2013 ;
Location in patent: Paragraph 0397 ;
