1.1: potassium carbonate; tert.-butylhydroperoxide; CuCl2·2H2O / dichloromethane / 25 - 30 °C / Inert atmosphere 2.1: trichlorophosphate / dichloromethane / 0 - 105 °C / Inert atmosphere 3.1: potassium carbonate / toluene / 25 - 115 °C / Inert atmosphere; Reflux 4.1: diisobutylaluminium hydride / dichloromethane / 0 - 5 °C / Inert atmosphere 4.2: 0 - 30 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '2037554', constants.ctx, '0')">sulfuric acid</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8127933', constants.ctx, '0')">copper(l) chloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />T=30 - 70&deg;C;&nbsp;&nbsp;Inert atmosphereReflux;&nbsp;<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 4-(N,N-dimethlyamino)pyridine; ammonia / toluene; water / 0 - 35 &deg;C / Inert atmosphere<br />2: copper(l) chloride; sulfuric acid / methanol / 30 - 70 &deg;C / Inert atmosphere; Reflux<br /> <br /> &nbsp;