1: 2-chloro-4-(morpholin-4-yl)-thieno[3,2-d]pyrimidine With isopropylmagnesium chloride in tetrahydrofuran T=0°C; 0.5 h; Inert atmosphere; 2: With n-butyllithium in tetrahydrofuran; hexane T=-10°C; Inert atmosphere; 3: 1-((4-(methylsulfonyl)piperazin-1-yl)methyl)-1H-benzotriazole With zinc(II) chloride in tetrahydrofuran; hexane T=-20 - 10°C; 0.5 h; Inert atmosphere;