(5-氨基-2-丁基-3-苯并呋喃基)[4-[3-(二丁基氨基)丙氧基]苯基]甲酮合成路线 （共 14 条）
反应条件
1: in toluene T=108°C; 3.5 h; 2: With sodium hydrogencarbonate in toluene T=60°C; 0.5 h;
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PATEL, Vipul, Kantibhai; PANDYA, Jayesh, Mohanlal
Patent: WO2012/32545 A1, 2012 ;
Location in patent: Page/Page column 36 ;
反应条件
triethylamine in dichloromethane T=20°C; 0.5 h;
参考文献
GLENMARK GENERICS LIMITED; SRIVASTAVA, Sachin; CRASTO, Anthony Melvin; GHARPURE, Milind; DEORE, Dinesh Bansilal; NARAYANAN, Suresh Babu
Patent: WO2012/7959 A1, 2012 ;
Location in patent: Page/Page column 23-24 ;
反应条件
1: (5-amino-2-butyl-benzofuran-3-yl)-[4-(3-dibutylamino-propoxy)phenyl]methanone; methanesulfonic acid in dichloromethane 2: trifluoromethanesulfonic anhydride With N-benzyl-N,N,N-triethylammonium chloride in n-heptane T=80 - 90°C; 5.5 h; 3: With sodium hydrogencarbonate in n-heptane; ethyl acetate
参考文献
SANOFI; FRIESZ, Antal; HUSZAR, Csaba
Patent: WO2012/131408 A1, 2012 ;
Location in patent: Page/Page column 12-13 ;
反应条件
1: anhydrous tetramethylammonium chloride / toluene / Reflux 2: sodium hydroxide / 1 h / 0 - 5 °C View Scheme
参考文献
SANOFI; FRIESZ, Antal; HUSZAR, Csaba
Patent: WO2012/131408 A1, 2012 ;
