2-丁基-3-(4-羟基苯甲酰基)-5-硝基苯并呋喃合成路线 （共 24 条）
反应条件
1: With AlCl3, aluminium chloride in chlorobenzene T=85°C; 4 h; 2: With water in chlorobenzene T=35 - 60°C;
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PATEL, Vipul, Kantibhai; PANDYA, Jayesh, Mohanlal
Patent: WO2012/32545 A1, 2012 ;
Location in patent: Page/Page column 32-33 ;
反应条件
1: With tributyl-amine in xylene 8 h; Molecular sieveReflux; 2: With hydrogenchloride; tributyl-amine T=200°C; 4 h; 3: With water in tert-butyl methyl ether T=20°C;
参考文献
SANOFI-AVENTIS; KRETZSCHMAR, Gerhard; KRAFT, Volker; ROSSEN, Kai; GRAeSER, Joachim
Patent: WO2010/136502 A1, 2010 ;
Location in patent: Page/Page column 20 ;
反应条件
1: With methyltrichloromonosilane; anhydrous iron chloride in chlorobenzene T=20 - 40°C; 3.45 - 5 h; 2: With ethanol in chlorobenzene T=0 - 30°C; 0.45 - 0.5 h; Product distribution / selectivity;
参考文献
Shasun Pharma Solutions Limited
Patent: US2008/154049 A1, 2008 ;
Location in patent: Page/Page column 7-9 ;
反应条件
1: With AlCl3, aluminium chloride in chlorobenzene T=60°C; 7 h; 2: With water in chlorobenzene T=60°C;
参考文献
WO2005/66149 A1, ;
Page/Page column 11-12 ;
反应条件
formic acid; trifluoroacetic acid T=45°C; 5 h; Inert atmosphere; Product distribution / selectivity;
参考文献
Wellig, Alain; Roduit, Jean-Paul; Dai, Danmei; Chen, Rongmin
Patent: US2011/178314 A1, 2011 ;
Location in patent: Page/Page column 9 ;
反应条件
acetic acid T=70 - 100°C; 25 h; Product distribution / selectivity;
参考文献
CAMBREX KARLSKOGA AB; HANSSON, Lars, O.; BERGH, Anders; ELKUND, Lars
Patent: WO2010/116140 A1, 2010 ;
Location in patent: Page/Page column 47; 48 ;
反应条件
acetic acid T=115°C; 3 h; Product distribution / selectivity;
参考文献
CAMBREX KARLSKOGA AB
Patent: WO2009/44143 A2, 2009 ;
Location in patent: Page/Page column 39-40 ;
反应条件
hydrogen bromide; acetic acid T=20°C; 6 h; Product distribution / selectivity;
参考文献
CAMBREX KARLSKOGA AB
Patent: WO2009/44143 A2, 2009 ;
Location in patent: Page/Page column 35 ;
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 4 h / 25 °C 2.1: AlCl3, aluminium chloride / chlorobenzene / 4 h / 85 °C 2.2: 35 - 60 °C View Scheme
参考文献
Journal of the Chinese Chemical Society, , vol. 58, # 7 p. 841 - 845
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 4 h / 25 °C 2.1: AlCl3, aluminium chloride / chlorobenzene / 4 h / 85 °C 2.2: 35 - 60 °C View Scheme
参考文献
Journal of the Chinese Chemical Society, , vol. 58, # 7 p. 841 - 845
