1: sulfuric acid / tetrahydrofuran / 1.75 h / 0 °C 2: potassium tert-butylate / iso-butyronitrile / 2 h / 0 - 95 °C 3: water / hydrogenchloride / iso-butyronitrile / 0.25 h / 0 °C 4: dichloromethane / 16 h / 20 °C 5: trifluoroacetic acid; formic acid / 5 h / 45 °C / Inert atmosphere View Scheme

1: triethylamine / dichloromethane / 1 h / 0 - 5 °C / |Inert atmosphere 2: AlCl3, aluminium chloride / nitrobenzene / 5 h / 140 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 2 h / 25 - 30 °C 4: bromine / dichloromethane / 1 h / 25 - 30 °C 5: AlCl3, aluminium chloride / dichloromethane / 15 - 20 °C 6: triethylamine / dichloromethane / 2 h / 25 - 30 °C 7: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 8: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 9: AlCl3, aluminium chloride / dichloromethane / 5.08 h / 0 - 30 °C 10: AlCl3, aluminium chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme

1: AlCl3, aluminium chloride / nitrobenzene / 5 h / 140 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 2 h / 25 - 30 °C 3: bromine / dichloromethane / 1 h / 25 - 30 °C 4: AlCl3, aluminium chloride / dichloromethane / 15 - 20 °C 5: triethylamine / dichloromethane / 2 h / 25 - 30 °C 6: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 7: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 8: AlCl3, aluminium chloride / dichloromethane / 5.08 h / 0 - 30 °C 9: AlCl3, aluminium chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 2 h / 25 - 30 °C 2: bromine / dichloromethane / 1 h / 25 - 30 °C 3: AlCl3, aluminium chloride / dichloromethane / 15 - 20 °C 4: triethylamine / dichloromethane / 2 h / 25 - 30 °C 5: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 6: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 7: AlCl3, aluminium chloride / dichloromethane / 5.08 h / 0 - 30 °C 8: AlCl3, aluminium chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme

1: bromine / dichloromethane / 1 h / 25 - 30 °C 2: AlCl3, aluminium chloride / dichloromethane / 15 - 20 °C 3: triethylamine / dichloromethane / 2 h / 25 - 30 °C 4: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 5: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 6: AlCl3, aluminium chloride / dichloromethane / 5.08 h / 0 - 30 °C 7: AlCl3, aluminium chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme

1: AlCl3, aluminium chloride / dichloromethane / 15 - 20 °C 2: triethylamine / dichloromethane / 2 h / 25 - 30 °C 3: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 4: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 5: AlCl3, aluminium chloride / dichloromethane / 5.08 h / 0 - 30 °C 6: AlCl3, aluminium chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme

1: triethylamine / dichloromethane / 2 h / 25 - 30 °C 2: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 3: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 4: AlCl3, aluminium chloride / dichloromethane / 5.08 h / 0 - 30 °C 5: AlCl3, aluminium chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme

1: triethylamine / dichloromethane / 1 h / 0 - 5 °C / |Inert atmosphere 2: AlCl3, aluminium chloride / nitrobenzene / 5 h / 140 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 2 h / 25 - 30 °C 4: bromine / dichloromethane / 1 h / 25 - 30 °C 5: AlCl3, aluminium chloride / dichloromethane / 15 - 20 °C 6: triethylamine / dichloromethane / 2 h / 25 - 30 °C 7: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 8: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 9: AlCl3, aluminium chloride / dichloromethane / 5.08 h / 0 - 30 °C 10: AlCl3, aluminium chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme

1: dichloromethane / 16 h / 20 °C 2: trifluoroacetic acid; formic acid / 5 h / 45 °C / Inert atmosphere View Scheme

1: potassium carbonate / butanone / 4 h / 81 - 82 °C 2: hydrogen / palladium 10 on activated carbon / ethanol / 2 h / 50 °C / 3750.38 Torr 3: pyridine / dichloromethane / 15 °C 4: sodium iodide / butanone / 16 h View Scheme