ammonium formate; platinum(IV) oxide in ethanol T=20°C; P=18751.9 Torr;

1.1: N,N-dioctyl-1-octylamine / tin(IV) chloride / toluene / 100 °C / Inert atmosphere 2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 3.1: sodium hydroxide / methanol / 0.5 h / Reflux 4.1: triethylamine; p-toluenesulfonyl chloride / benzene / Inert atmosphere; Reflux 5.1: bis(dibenzylideneacetone)-palladium(0); Pd0(tris(tert-butyl)phosphine)2 / toluene / 2 h / 100 °C / Inert atmosphere 6.1: hydrogenchloride; water / toluene; diethyl ether 6.2: pH 10 View Scheme

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 2.1: sodium hydroxide / methanol / 0.5 h / Reflux 3.1: triethylamine; p-toluenesulfonyl chloride / benzene / Inert atmosphere; Reflux 4.1: bis(dibenzylideneacetone)-palladium(0); Pd0(tris(tert-butyl)phosphine)2 / toluene / 2 h / 100 °C / Inert atmosphere 5.1: hydrogenchloride; water / toluene; diethyl ether 5.2: pH 10 View Scheme

1.1: bis(dibenzylideneacetone)-palladium(0); Pd0(tris(tert-butyl)phosphine)2 / toluene / 2 h / 100 °C / Inert atmosphere 2.1: hydrogenchloride; water / toluene; diethyl ether 2.2: pH 10 View Scheme

1.1: sodium hydroxide / methanol / 0.5 h / Reflux 2.1: triethylamine; p-toluenesulfonyl chloride / benzene / Inert atmosphere; Reflux 3.1: bis(dibenzylideneacetone)-palladium(0); Pd0(tris(tert-butyl)phosphine)2 / toluene / 2 h / 100 °C / Inert atmosphere 4.1: hydrogenchloride; water / toluene; diethyl ether 4.2: pH 10 View Scheme

1.1: triethylamine; p-toluenesulfonyl chloride / benzene / Inert atmosphere; Reflux 2.1: bis(dibenzylideneacetone)-palladium(0); Pd0(tris(tert-butyl)phosphine)2 / toluene / 2 h / 100 °C / Inert atmosphere 3.1: hydrogenchloride; water / toluene; diethyl ether 3.2: pH 10 View Scheme

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 2.1: sodium hydroxide / methanol / 0.5 h / Reflux 3.1: triethylamine; p-toluenesulfonyl chloride / benzene / Inert atmosphere; Reflux 4.1: bis(dibenzylideneacetone)-palladium(0); Pd0(tris(tert-butyl)phosphine)2 / toluene / 2 h / 100 °C / Inert atmosphere 5.1: hydrogenchloride; water / toluene; diethyl ether 5.2: pH 10 View Scheme

ammonia in tetrahydrofuran; tert-butyl methyl ether; water T=200°C;

1.1: pyridine / dichloromethane / 0.08 h / 20 °C 1.2: 0.5 h / 20 °C 2.1: pyridine / dichloromethane / 0.25 h / 30 - 35 °C 2.2: 5 h / 30 - 35 °C 3.1: anhydrous iron chloride / dichloromethane / 5 - 40 °C 4.1: sodium hydroxide / methanol / 2 h / 65 °C View Scheme