1: anhydrous iron chloride / dichloromethane / 1.25 h / 5 - 40 °C 2: water; AlCl3, aluminium chloride / 1,2-dichloro-ethane / 7.5 h / 64 - 66 °C 3: potassium carbonate / butanone / 8 h 4: ethanol; sodium / 0.5 h View Scheme

1: anhydrous iron chloride / dichloromethane / 4.25 h 2: ethanol; sodium / 0.5 h View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11343346', constants.ctx, '0')">potassium phosphate</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11405916', constants.ctx, '0')">copper(l) iodide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1699442', constants.ctx, '0')">N-methyl-glycine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />&nbsp;Reflux;&nbsp;<br /> <br /> &nbsp;

<b>Multi-step reaction with 7 steps<br /> </b>1.1: N,N-dioctyl-1-octylamine / tin(IV) chloride / toluene / 100 &deg;C / Inert atmosphere<br />2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 &deg;C / Inert atmosphere<br />3.1: sodium hydroxide / methanol / 0.5 h / Reflux<br />4.1: triethylamine; p-toluenesulfonyl chloride / benzene / Inert atmosphere; Reflux<br />5.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; Pd⁰(tris(tert-butyl)phosphine)₂ / toluene / 2 h / 100 &deg;C / Inert atmosphere<br />6.1: hydrogenchloride; water / toluene; diethyl ether<br />6.2: pH 10<br />7.1: triethylamine / dichloromethane / 0.5 h / 10 &deg;C / Inert atmosphere<br /> <br /> &nbsp;