1: 1.) aq. NaHCO3, 2.) pyridine / 1.) Et2O, RT, 16 h, 2.) from 8 deg C to 10 deg C, 48 h 2: 87 percent / Cs2CO3 / acetonitrile / 6 h / Ambient temperature 3: 73 percent / tetrabutylammonium fluoride trihydrate (Bu4NF) / tetrahydrofuran / 24 h / Ambient temperature View Scheme

1: 53 percent / pyridine 2: 87 percent / Cs2CO3 / acetonitrile / Ambient temperature 3: 73 percent / tetrabutylammonium fluoride View Scheme