copper(l) iodide; tris(dibenzylideneacetone)dipalladium (0); triphenyl-arsane in various solvent(s) T=60°C; Stille coupling conditions; 13 h;

hydrogenchloride 2 h; Ambient temperature;

1: 90 percent / 0.1 N HCl / methanol / 0.75 h / 20 °C 2: 15 percent / Pd2(dba)3; AsPh3; CuI / various solvent(s) / 13 h / 60 °C View Scheme

1: 1.) aq. NaHCO3, 2.) pyridine / 1.) Et2O, RT, 16 h, 2.) from 8 deg C to 10 deg C, 48 h 2: 85 percent / Cs2CO3 / acetonitrile / 24 h / Ambient temperature 3: 90 percent / 0.1 N methanolic HCl / 2 h / Ambient temperature View Scheme

1: 85 percent / Cs2CO3 / acetonitrile / 24 h / Ambient temperature 2: 90 percent / 0.1 N methanolic HCl / 2 h / Ambient temperature View Scheme

pyridine Ambient temperature;