(R)-3-甲磺酰氧基吡咯烷-1-羧酸叔丁酯合成路线 （共 6 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C; 2.5 h;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0150 ;
反应条件
triethylamine in dichloromethane T=0°C; 3.5 h;
参考文献
ASTRAZENECA AB
Patent: WO2006/73366 A1, 2006 ;
Location in patent: Page/Page column 185 ;
WO 2006/073366 A1
反应条件
1: di-tert-butyl dicarbonate; 3-(R)-(-)-hydroxypyrrolidine hydrochloride With triethylamine in methanol T=0 - 20°C; 5.5 h; 2: methanesulfonyl chloride in dichloromethane T=0 - 20°C;
参考文献
WO2011/104337 A1, ;
Page/Page column 73-74 ;
WO 2011/104337 A1
反应条件
1.1: triethylamine / methanol / 0 °C 1.2: 5.5 h / 0 - 20 °C 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C View Scheme
反应条件
in N,N-dimethyl-formamide T=80°C; 16 h;
参考文献
US2011/166121 A1, ;
Page/Page column 43 ;
US 20110166121 A1
反应条件
tetra-N-butylammonium azide in acetonitrile
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1500643 A1, 2005 ;
Location in patent: Page 67 ;
EP 1500643 A1
