1-Boc-4-甲烷磺酰氧基哌啶合成路线

参考文献

OTSUKA PHARMACEUTICAL CO., LTD.
Patent: WO2005/92832 A1, 2005 ;
Location in patent: Page/Page column 44-46 ;

2075-45-84-溴吡唑+

141699-59-41-Boc-4-甲烷磺酰氧基哌啶

877399-50-34-(4-溴吡唑-1-基)哌啶-1-甲酸叔丁酯

参考文献

Journal of Medicinal Chemistry, , vol. 54, # 12 p. 4092 - 4108

591-20-8间溴苯酚+

141699-59-41-Boc-4-甲烷磺酰氧基哌啶

790667-54-81-BOC-4-(3-溴苯氧基)哌啶

参考文献

AURIGENE DISCOVERY TECHNOLOGIES LIMITED; UM PHARMAUJI SDN. BHD; GUMMADI, Venkateshwar, Rao; HOSAHALLI, Subramanya; NANDURI, Srinivas; AGGUNDA RENUKAPPA, Girish
Patent: WO2014/6554 A1, 2014 ;
Location in patent: Page/Page column 43; 44 ;

141699-59-41-Boc-4-甲烷磺酰氧基哌啶

877399-74-14-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔丁酯

参考文献

Blake, James F.; Boyd, Steven Armen; De Meese, Jason; Fong, Kin Chiu; Gaudino, John J.; Kaplan, Tomas; Marlow, Allison L.; Seo, Jeongbeob; Thomas, Allen A.; Tian, Hongqi; Cohen, Frederick; Young, Wendy B.
Patent: US2007/238726 A1, 2007 ;
Location in patent: Page/Page column 124 ;
US 20070238726 A1

269410-08-44-吡唑硼酸频哪醇酯+

141699-59-41-Boc-4-甲烷磺酰氧基哌啶

877399-74-14-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔丁酯

参考文献

OSI PHARMACEUTICALS, LLC; HOMBERGER, Keith, R.; BERGER, Dan, M.; CHEN, Xin; CREW, Andrew, P.; DONG, Hanqing; KLEINBERG, Andrew; LI, An-Hu; MA, Lifu; MULVIHILL, Mark, J.; PANICKER, Bijoy; SIU, Kam, W.; STEINIG, Arno, G.; TARRANT, James, G.; WANG, Jing; WENG, Qinghua; SANGEM, Rajaram; GUPTA, Ramesh, C.
Patent: WO2011/100502 A1, 2011 ;
Location in patent: Page/Page column 37 ;
WO 2011/100502 A1

141699-59-41-Boc-4-甲烷磺酰氧基哌啶

208245-70-94-甲基硫代哌啶盐酸盐

参考文献

EXELIXIS, INC.; RICE, Kenneth
Patent: WO2012/71509 A2, 2012 ;
WO 2012/071509 A2

141699-59-41-Boc-4-甲烷磺酰氧基哌啶

85838-94-4N-BOC-1,2,3,6-四氢吡啶

参考文献

US2009/163472 A1, ;

Page/Page column 27 ;
US 20090163472 A1

2022-85-7氟胞嘧啶+

141699-59-41-Boc-4-甲烷磺酰氧基哌啶

1033840-03-7

参考文献

Organic Process Research and Development, , vol. 13, # 4 p. 807 - 811

141699-59-41-Boc-4-甲烷磺酰氧基哌啶

224779-27-51-Boc-3-羟基-1,2,3,6-四氢吡啶

参考文献

XI, Ning; WANG, Tingjin; YI, Lei
Patent: WO2013/138210 A1, 2013 ;

3469-69-0+

141699-59-41-Boc-4-甲烷磺酰氧基哌啶

877399-73-0

参考文献

Shanghai Institute Materia Medica, Chinese Academy Of Sciences; DUAN, Wenhu; GENG, Meiyu; CHEN, Fang; AI, Jing; CHEN, Yi; ZHAN, Zhengsheng; LV, Yongcong; WANG, Ying; DING, Jian
Patent: EP2650293 A1, 2013 ;
Location in patent: Paragraph 0195; 0196 ;